Suzetrigine (Journavx) for adults with moderate to severe acute pain

Two experts in treating pain at MUSC Health are looking forward to the arrival of a new non-opioid pain medication next month. The Food and Drug Administration has approved the use of suzetrigine (Journavx) for adults with moderate to severe acute pain, the kind a person would feel after surgery or an injury.  

How Your Brain Creates ‘Aha’ Moments and Why They Stick

 They observed that when a participant noticed a hidden object, brain activity increased in the ventral occipitotemporal cortex (VOTC), a region responsible for recognizing visual patterns in the environment; the amygdala, which processes both positive and negative emotions; and the hippocampus, a deep-brain structure involved in handling memories. This activity was greater for experiences rated more certain and emotionally positive — in other words, more insightful ones.

The hippocampus is sometimes known as the brain’s “mismatch detector,” Becker said, because it reacts when an input doesn’t align with expectations. In this case, insight leads a once-meaningless image to gain meaning, going against the brain’s predictions.

https://www.quantamagazine.org/how-your-brain-creates-aha-moments-and-why-they-stick-20251105/

Dorsal Root Ganglion Block and Pulsed Radiofrequency

Using pulsed radiofrequency of dorsal root ganglion, pain signals to the brain are interrupted with an electrical pulse, meaning the patient does not feel the same pain as he or she did previously.

Health Information

Ticker: Don’t Die of Heart Disease: https://news.ycombinator.com/item?id=45857053

NHS Health information

https://healthify.nz/medicines-a-z/s/steroids-long-term

University health research

This is lacking in India

Linux on the Fujitsu Lifebook U729

It’s a delightful laptop, and Linux runs flawlessly, and all the hardware things I’ve needed run OOTB. The only difficulty I had was in disabling Secure Boot, but I figured out how to do it, which I explain below. 

https://news.ycombinator.com/item?id=45937989

STATE OF AI REPORT 2025

 The State of AI Report is the most widely read and trusted analysis of key developments in AI. Published annually since 2018, the open-access report aims to spark informed conversation about the state of AI and what it means for the future. Produced by AI investor Nathan Benaich and Air Street Capital.

https://www.stateof.ai/

https://news.ycombinator.com/item?id=45564042

Gleam Language Gleam.Run

The power of a type system, the expressiveness of functional programming, and the reliability of the highly concurrent, fault tolerant Erlang runtime, with a familiar and modern syntax.

 Reliable and scalable

Running on the battle-tested Erlang virtual machine that powers planet-scale systems such as WhatsApp and Ericsson, Gleam is ready for workloads of any size.

Thanks to its multi-core actor based concurrency system that can run millions of concurrent green threads, fast immutable data structures, and a concurrent garbage collector that never stops the world, your service can scale and stay lightning fast with ease.

https://gleam.run/

Fumadocs is a documentation framework

 Fumadocs (Foo-ma docs) is a documentation framework, designed to be fast, flexible, and composes seamlessly into your React framework.

Fumadocs was created because the creator Fuma wanted a more customisable experience for building docs, to be a docs framework that is not opinionated, a "framework" that you can break.

https://fumadocs.dev/showcase

https://fumadocs.dev/docs/ui/what-is-fumadocs

https://fumadocs.dev/docs/ui/comparisons

AirPods libreated from Apple's ecosystem

A cool project, when you want to use AirPods outside of Apples ecosystem. Sadly, you have to use a rooted android device with a small patch due to a bug in the Android Bluetooth implementation. 

https://news.ycombinator.com/item?id=45941605 

Using Run Above Instance

• RunAbove uses SSH keys only, no root password.
• Instructions for using SSH keys on their website do not work well.
• PuTTYgen, number of bits should be 4096
• Copy paste public key from PuTTYgen directly on to the website. If we save the public key and try to copy it, it won't work.
• Save the private key file.
• Save the public key as well, but not from the PuTTYgen interface, instead copy from there to a text file.
• Connect as suggested: https://community.runabove.com/kb/en/instances/create-ssh-keys.html

Mechanical Consistency

But because it is so typically in our best interests to be consistent, we easily fall into the habit of being automatically so, even in situations where it is not the sensible way to be. When it occurs unthinkingly, consistency can be disastrous. Nonetheless, even blind consistency has its attractions.

First, like most other forms of automatic responding, it offers a shortcut through the density of modern life. Once we have made up our minds about an issue, stubborn consistency allows us a very appealing luxury: We really don’t have to think hard about an issue anymore. We don’t have to sift through the blizzard of information we encounter every day to identify relevant facts; we don’t have to expend the mental energy to weigh the pros and cons; we don’t have to make any further tough decisions. Instead, all we have to do when confronted with the issue is to turn on our consistency tape, whirr, and we know just what to believe, say, or do. We need only believe, say or do whatever is consistent  with our earlier decision.

The allure of such luxury is not to be minimized. It allows us a convenient, relatively effortless, and efficient method for dealing with complex daily environments that make severe demands on our mental energies and capacities. It is not hard to understand, then, why automatic consistency is a difficult reaction to curb. It offers us a way to evade the rigors of continuing thought. And as Sir Joshua Reynolds noted, “There is no expedient to which a man will not resort to to avoid the real labor of thinking”.

There is a second, more perverse attraction of mechanical consistency as well. Sometimes it is not the effort of hard, cognitive work that makes us shirk thoughtful activity, but the harsh consequences of that activity. Sometimes it is the cursedly clear and unwelcome set of answers provided by straight thinking that makes us mental slackers. There are certain disturbing things we simply would rather not realize. Because it is a preprogrammed and mindless method of responding, automatic consistency can supply a safe hiding place from those troubling realizations. Sealed within the fortress walls of rigid consistency, we can be impervious to the sieges of reason.

From: Influence, The Psychology of Persuasion

Removing Ultrabay Lenovo Y500

• Remove battery
• Unlock switch next to M 2.5x10
• Locate unlock switch in the grille, somwhere near center. Push it down and hold while pulling out the ultrabay.

1dollarscan

If you have a lot of books lying around, 1dollarscan.com converts them to searchable pdf. I find their prices reasonable, $1 for 100 pages (for books). Do note that your book will not be returned back.

Barclays Credit Card

Don't ever apply for Barclay's credit card (or cards managed by Barclays - such as US Airways). They need proof of citizenship or permanent residency.

The Expendables

Yin Yang: It's difficult.

Barney Ross: What?

Yin: My life is difficult. I need more money.

Barney: Why that?

Yin: I work harder than the rest.

Barney: No, you don't.

Yin: Yes, I do! Everything is harder for me. When I'm hurt, wound is bigger, 'cause I'm smaller. When I travel I need to go farther.

Barney: I know, because you're smaller, right?

Yin: Yes.

[awkward silence]

Yin: I need more money.

Barney: I know, you told me.

Obihai Obi100

• Get OBi100.
• Get a Google Voice number. Place a call via Gmail.
• Login to Google Voice, Phones, check ONLY Google Chat. OBi uses Google Chat/XMPP.
• Find OBi100 IP address from your router. Login to the IP, default password admin, admin.
• Change Auto Provisioning - disable Firmware Update and Auto Provisioning
• Change Network Settings - Static IP, Subnet Mask, Default Gateway, DNS.
• Register at obitalk.com. This is simple, just register online and call the number from your phone, your device serial number and MAC address will be registered with obitalk.com
• On obitalk.com, configure Service Providers, select Google Voice and enter Gmail credentials. This should automatically setup your device for GV incoming and outgoing.
• Update: Login to obitalk.com. You will see 2 entries under My OBi Endpoints. Select OBi 100 (or 110 if you have that). Under "Configure Voice Services", you will find Google Voice setup. This will automatically configure the "Service Provider 1". 

Some folks may have a problem with incoming calls. A possible solution is to use SIPGATE. See Amazon reviews for setup details.

The Michigan Telephone blog

Other ways of using OBi.

5BX program

From Discussion


No kidding! I used to have frequent back pain, with aches that wouldn't go away even after an age of stretching.

Six years ago I started on the RCAF's old 5BX program (a quick Google search will lead you to the booklet that describes it -- dead simple) and, in exchange for 11 minutes of exercise a day on an open floor, had the body I've always wanted within a year.

I've since moved on to weights and other gym-like stuff and have not had back pain in years.

It's so stupidly obvious I'm kicking myself for it now: If you have decent muscle to support all those bones and tendons up your back, they won't be straining themselves to the point of pain while supporting your body.

Yeah, yeah, 5BX is great! While a certain rare exercise machine gives the most relief, one simple 5BX back exercise (chart 1, exercise 3) is as effective, provided I do it regularly.

The only thing that has helped is exercise. Strengthening your back (especially lower) is probably going to help more than anything else. Squats and deadlifts in particular.

Pull ups will do wonders as well.

I agree, but I wish I could caution my younger self about the risk of low back injuries from certain weightlifting activities

1) You can develop very strong lower back muscles (primarily the extensors), but don't challenge those muscles when they're nearing their endurance limit.

2) If your femurs are long relative to your tibia, don't try to force yourself to perform as heavy or with the same form and depth on squats, deadlifts, or cleans, as more normal folks. At low depth, your back will consistently be more parallel to the floor than upright, dramatically increasing shear across your spine.

Of course, it goes without saying that you shouldn't round your back excessively while bearing significant load, especially if it's far (horizontally) from your hips. It's not necessarily that a rounded back is automatically dangerous, but in general, if you're bracing your abdominal/back muscles (which will prevent rounding), you're less at risk of injury.

Outside of seeing a doctor to see if there's something seriously screwed up with your back, I'd offer these 3 pieces of advice I had to learn about the hard way.

1.) Massage.

You may not think it's the manliest thing ever, but if you can afford it you should find a good local masseuse and get yourself an hour session. Even if you go once and never go again, you'll get an education in just how kinked up your back and shoulders probably are.

I tweaked my back lifting a lawn mower out of my car a few years ago and didn't think much of it at the time. Over the next few weeks I started to have all kinds of shoulder problems and other various pain to the point where my arms were getting tingly and I couldn't sit and code for more than 30 minutes at a time.

Long story short, I went through a few doctors before I finally just decided to see a masseuse and see if it helped. I was lucky to find someone that knew what they were doing and helped get me straightened out. It took about 5 sessions over 5 weeks, but I've never had problems since.

2.) Trigger points.

Learn what they are and how you can fix them. This was my problem that the masseuse turned me on to. Trigger points are essentially little micro-knots in your muscle fibers that can add up to cause big problems for you. For me, lifting that mower was really just the straw that broke the camel's back. It just exacerbated all the trigger point problems I'd been creating over years of coding and not stretching out my back and shoulders properly.

If you know where the common trigger points creep up and how to get rid of them you can save yourself a lot of pain and downtime (not to mention massage bills).

Buy these two things: The Trigger Point Therapy Workbook (http://www.amazon.com/Trigger-Point-Therapy-Workbook-Self-Tr...) and a TheraCane (http://www.amazon.com/Thera-Cane-Theracane-TheraCane/dp/B000...)

The book will show you how to identify and treat the trigger points all over your body, and the TheraCane will help you reach the places on your back that you can't reach yourself.

3.) Yoga.

Once you get all your issues straightened out, yoga and/or a good daily stretching regimen can help keep you kink free.

Hopefully some of this advice is helpful. I was really messed up for a while until I figured all this out.

exercises for back problems

I have 3 squashed discs in my lower back from a skateboarding injury. I've tried everything for back pain. Before I share what works for me, I'll say that if you don't have a structural injury you probably just have very weak "core" muscles and the best thing you can do is get into a general state of good fitness and then add in some core strengthening exercises.

After doing tons of PT, and trying everything from yoga to pilates to accupuncture to cyclobenzeprine, I figured out three main exercises that strengthen the muscles in the lower back:

- "superman": lay on your stomach on the floor. raise your left arm and right leg up at the same time. hold for a count of five. repeat on other side. do this 10 times for each side.

- "planks": this is like a pushup but you're on your elbows and instead of doing a pushup, you just hold in that position. It sounds easy but is very hard if you don't have strong abs. try to work up to 3-5 sets of 60 seconds at a time.

- "bird dog": like the superman but you're on your knees and hands, doggy style. raise left leg and right arm at the same time, hold for count of 5. alternate. do 10.

Those three things, and being generally in shape have helped my back more than anything else I've tried. You can find videos of them on youtube if you google those exercise names with "core fitness" or similar search strings added in.

Other lifestyle changes are good, too. Don't sit down in a pile for 8 hours at a time. Get up and move around, even if you're just getting out of your chair at least once an hour. Change your position. Sit on an exercise ball for a while, lie down on a couch with a laptop for a while, work standing up for a while. Go for a walk at least an hour a day.

I've found that pilates is much better for back care than yoga. many of the yoga moves are not good for your back if you have slipped discs. in particular, "downward dog" which is the staple move of most yogas is not good if you actually have a back injury like mine. Pilates arose out of rehab so most of the moves are safer for your back. I mention these activities because one of the side effects of back problems (or sometimes the cause of back problems) is very tight hamstrings. You'll need to do some sort of stretching to get the hamstrings back in order and I've found this easier to do in a structured, class context.

I'll be semi controversial and say that you want to have strong abs, but you DON'T want to do situps. do planks instead. Situps strengthen your abs while pulling your back into the same position that makes it hurt. planks strengthen your abs but you're also extended and working all your stabilization muscles at the same time.

Maybe Americans just aren’t dumb enough to keep buying houses?

Psychologically, a person who just lost enough money to have paid for 5-10 years of rent is not a very likely candidate to go back into the market where he was just burned.
Thus the more houses are sold, the worse the buyer-seller ratio will get. Every sale has a roughly 37% chance of removing a person from the real estate ownership market. More and more Americans will be conditioned to the idea that home ownership is a waste of time and money, not to mention the inflexibility that it imposes on a person who might otherwise have been able to get a better job by moving.
Summary: Why would house prices continue to fall then? The longer that house prices fall, the more people will critically assess whether it makes any financial sense to own and conclude “it does not”. They withdraw themselves from the market of potential buyers, at least for 10 years or so until they forget what wounds they suffered and how boring they were when they owned.

Vivint - Home Automation

When you’re looking for a comprehensive way to connect the technologies that run your home, the Vivint Home package is the answer. It features all the products in our Security and Energy packages, but also gives you a lot more. It includes automatic door locks, video surveillance, and non-emergency alerts. With only a $199 activation fee* plus the monthly monitoring charge, this package provides simple, affordable home automation. 

From premier security, to heating and cooling, to access control and video surveillance, our Home package meet your needs today while helping you prepare for a smarter future. Its additional products include automatic door locks, video surveillance, and non-emergency alerts. And you can manage them all through your computer or smart phone, so you always know exactly what’s happening at your home—even when you’re not there.